Plant pathogens affect the availability of food and feedstock needed to support the demands of a growing human population. Plant diseases are ultimately determined by the interactions between plants (hosts) and a given pathogen, which are very specific and, mediated by the genetic makeup of both the plant and the pathogen. Research in my lab focuses on identifying plant genes conferring broad resistance against bacterial pathogens. Using the model plant Arabidopsis thaliana in conjunction with tools from genetics, molecular and cell biology, we are working to decipher how those genes function in the plant, how they work in the presence of a bacterial pathogen and how their function is integrated with known signal transduction cascades. In parallel, we also investigate how the bacterial pathogen Pseudomonas syringae is able to cause disease in a wide range of crops, specifically investigating bacterial virulence factors and how do they determine host specificity. We are also investigating the bacterial pathogen Burkholderia glumae and Burkholderia gladioli, an emerging pathogen, causing bacterial panicle blight in rice. We are discovering genes involved in Burkholderia pathogenicity analyzing how they contribute to the different stages in the pathogen's life cycle.
PLPA 6503 - Phytobacteriology
B.S. Microbiology, Universidad de Los Andes (Colombia)
M.S. Genetics, Purdue University
Ph.D. Plant Pathology, Cornell University
- Rojas, C.M., Senthil-Kumar, M., Tzin, V., and Mysore, K.S. (2014). Regulation of primary plant metabolism during plant-pathogen interactions and its contribution to plant defense. Frontiers in Plant Science, 5:17.
- Lee, S., Rojas, C. M., Ishiga, Y., Pandey, S., and Mysore, K.S. Arabidopsis (2013). Arabidopsis heterotrimeric G-proteins play a critical role in host and nonhost resistance against Pseudomonas syringae pathogens. PLoS One. 8(12):e82445.
- Rojas, C. M., and Mysore, K.S. (2012). Glycolate oxidase is an alternative source of H2O2 production during plant defense responses and functions independently from NADPH oxidase. Plant Signaling and behavior. July; 7 (7): 1-4.
- Anand, A., Rojas C. M., Tang, Y., and Mysore K. S. (2012). Several components of SKP1/Culin/F-box E3 ubiquitin ligase complex and associated factors play a critical role in Agrobacterium-mediated plant transformation. New Phytologist. 195 (1): 203-216.
- Rojas, C. M., Senthil-Kumar, M., Wang, K., Ryu, C. M., Kaundal, A., and Mysore, K. S. (2012). Glycolate oxidase plays a major role furing nonhost resistance responses by modulating ROS-mediated signal transduction pathways. The Plant Cell. 24:336-352.
- Tadege, M., Lin, H., Bedair, M., Berbel, A., Wen, J., Rojas, C. M., Niu, L., Tang, Y., Sumner, L., Ratet, P., McHale, N.A., Madueno, F., Mysore, K. S. (2011). STENOFOLIA Regulates Blade Outgrowth and Leaf Vascular Patterning in Medicago truncatula and Nicotiana sylvestris. The Plant Cell. 23:2125-2142.
- Yap, M. N., Rojas, C. M., Yang, C. H., and Charkowski, A. O. (2006). Harpin mediates cell aggregation in Erwinia chrysanthemi 3937. Journal of Bacteriology. 188(6): 2280-2284.
- Rojas, C. M., Harn, J. H., Schechter, L. M., Kim, J. F., Beer, S. V., and Collmer, A. (2004). The Erwinia chrysanthemi EC16 hrp/hrc gene cluster encoes and active Hrp type III secretion system that is flanked by virulence genes functionally unrelated to the Hrp system. Molecular Plant Microbe Interactions. 17(6): 644-653.
- Ham, J. H., Cui Y., Alfano, J. R., Rodriguez-Palenzuela, P., Rojas, C. M., Chatterjee, A. K., and Collmer, A. (2004). Differential expression and contribution to virulence of hrpN, pelL, peIE, and the cloning and mutagenesis of ahll, the luxl homolog, in Erwinia chrysanthemiEC16. Molecular Plant Microbe Interactions. 17(2): 184-94.
- Deng, W. L., Rehm, A., Charkowski, A., Rojas, C. M., and Collmer, A. (2003). Isolation and characterization of the exchangeable effector loci from different Pseudomonas syringae pathovars with emphasis on P. syringae pv. syringae B728a. Journal of Bacteriology. 185(8):2592-2602.
- Rojas, C., M., Ham, J. H., Deng, W. L., Doyle, J. J., and Collmer, A. (2002). HecA is a founding member of a class of adhesins in plant pathogenic bacteria and contributes to attachment, autoagglutination and virulence of Erwinia chrysanthemi. Proceedings of the National Academy of Sciences. U S A. 99(20):13142-7.